Abstract:

Epithelial tumor of lacrimal gland is a common orbital tumor, and the common benign and malignant tumors are respectively lacrimal pleomorphic adenoma and adenoid cystic carcinoma. Lacrimal pleomorphic adenoma is prone to relapse, malignant change, adenoid cystic carcinoma is not satisfactory to operate simply, easy to relapse, and poor prognosis. In recent years, molecular biology studies have found that oncogene PLAG1 and HMGA2 have high sensitivity and specificity in the diagnosis of pleomorphic adenoma. MYB gene expression can be used as the molecular diagnostic index of adenoid cystic carcinoma. Tumor-suppressor genes INK4a - ARF, signaling pathways, such as IL-6 / JAK/STAT3 and Notch, matrix metalloproteinases (MMP) and cyclooxygenase 2 (COX-2) and so on, have some effect on the development, recurrence, metastasis and transformation of the epithelial tumor of lacrimal gland.